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Updated: Jul 3, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

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Prognosis Using Modified Albumin-Bilirubin Grade in Resected Biliary Tract Cancer: A Multicenter Propensity

Toru Takahashi¹, Hiroaki Yanagimoto¹, Masayuki Akita¹

¹Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Cancer Diagnosis & Prognosis

|July 2, 2026

Summary

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The modified albumin-bilirubin (mALBI) grade predicts survival in patients with biliary tract cancer (BTC). A high mALBI grade is linked to shorter overall survival (OS) and recurrence-free survival (RFS) after resection.

Area of Science:

Hepatology
Gastroenterology
Surgical Oncology

Background:

The modified albumin-bilirubin (mALBI) grade is a novel liver function assessment.
It is increasingly utilized as a prognostic factor in gastrointestinal cancers.

Purpose of the Study:

To evaluate the prognostic value of the mALBI grade in patients undergoing curative resection for biliary tract cancer (BTC).
To assess the association of mALBI grade with overall survival (OS) and recurrence-free survival (RFS).

Main Methods:

Retrospective analysis of 634 patients who underwent curative resection for BTC.
Calculation of preoperative mALBI grade using albumin and total bilirubin levels.
Propensity score-matching and Cox proportional hazards regression to analyze survival outcomes.

Keywords:

Modified albumin-bilirubin grade adjunctive therapy biliary tract cancer multicenter study overall survival

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Last Updated: Jul 3, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Main Results:

A high mALBI grade was significantly associated with poorer OS (44 vs. 70 months) compared to the low mALBI group.
Multivariate analysis confirmed high mALBI grade as an independent predictor of poor OS (HR=1.584) and RFS (HR=1.447).

Conclusions:

Preoperative mALBI grade is a valuable prognostic indicator in resected BTC.
It aids in risk stratification and prognostic evaluation for improved patient management.