Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...

Mitral Stenosis I: Introduction

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

Mitral Stenosis III: Medical Management

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...

Mitral Stenosis IV: Nursing Management

Mitral Stenosis IV: Nursing Management

A comprehensive nursing assessment is essential for patients with valvular heart disease, which involves any dysfunction of the heart valves that could impact blood flow and overall heart function.Subjective Data Collection:Chief Complaint and Present Illness: Start with the patient's primary concerns, focusing on the onset, duration, and progression of cardiac symptoms such as dyspnea, fatigue, chest pain, and palpitations.Past Medical History: Collect detailed information on any previous...

Mitral Valve Prolapse II: Assessment and Management

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The 2025 WAO Guidelines for the classification, diagnosis, and treatment of hereditary angioedema, with consideration of worldwide disparities.

The World Allergy Organization journal·2026

Same author

Evaluation of intestinal fungal and parasitic infection in iranian primary immunodeficiency patients.

Molecular biology reports·2026

Same author

Relationship Between ECG and Left Atrial Hemodynamics in Patients with Mitral Stenosis.

Heart views : the official journal of the Gulf Heart Association·2025

Same author

Comparison of basophil activation testing and component-resolved diagnosis in patients with cross-reactive intradermal results after anaphylactic reactions to hymenoptera venom.

Scientific reports·2025

Same author

Development of eosinophilic esophagitis during wheat oral immunotherapy in children: a retrospective cohort analysis.

Immunotherapy·2025

Same author

Cardiac Assessment of Individuals with Opioid Use Disorder under Methadone Treatment.

Journal of research in pharmacy practice·2025

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Diastolic Dysfunction in Mitral Stenosis: Invasive Versus Noninvasive Methods.

Khadije Mohammadi¹, Amin Mahdavi¹, Mohammad Masoumi¹

¹Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.

Journal of Cardiovascular Echography

|July 2, 2026

Summary

Noninvasive imaging effectively identifies elevated left ventricular end-diastolic pressure in severe mitral stenosis patients. Isovolumic relaxation time and diastolic strain rate are key indicators for assessing diastolic function.

Keywords:

Diastolic dysfunction echocardiography isovolumic relaxation time mitral stenosis strain rate

More Related Videos

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

Related Experiment Videos

Last Updated: Jul 3, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

Area of Science:

Cardiology
Medical Imaging
Cardiovascular Physiology

Background:

Assessing left ventricular (LV) diastolic function in severe mitral stenosis (MS) is clinically challenging.
Elevated LV end-diastolic pressure (LVEDP) is a critical indicator of diastolic dysfunction.
Noninvasive methods are sought to accurately estimate LVEDP, avoiding invasive procedures.

Purpose of the Study:

To evaluate the efficacy of noninvasive echocardiographic parameters in detecting elevated LVEDP in severe MS patients.
To compare the diagnostic value of various echocardiographic indices against invasive LVEDP measurements.

Main Methods:

Sixty-three patients with severe MS undergoing Percutaneous Transluminal Mitral Commissurotomy were studied.
Echocardiographic assessments included isovolumic relaxation time (IVRT), IVRT/T_E-e', diastolic strain rate, LV ejection fraction, LV global longitudinal strain, pulmonary vein diastolic deceleration time, and Myocardial Performance Index.
Invasive LVEDP measurements served as the reference standard.

Main Results:

LVEDP correlated with IVRT, IVRT/T_E-e', and diastolic strain rate in patients with atrial fibrillation and sinus rhythm.
In sinus rhythm, LVEDP also correlated with LV ejection fraction, LV global longitudinal strain, pulmonary vein diastolic deceleration time, and Myocardial Performance Index.
IVRT, IVRT/T_E-e', and diastolic strain rate demonstrated the highest accuracy in identifying elevated LVEDP.

Conclusions:

Noninvasive imaging parameters, particularly IVRT, IVRT/T_E-e', and diastolic strain rate, are valuable tools for identifying elevated LVEDP in severe MS.
These echocardiographic indices offer a reliable noninvasive approach to assess diastolic function in this patient population.