Related Experiment Video
Updated: Jul 3, 2026

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
Published on: January 17, 2012
Emerging roles of amphiregulin in disease pathogenesis and therapeutic promise
Nana Li1,2,3, Junyi He1,2,3, Meilin Liu1,2,3
1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Abstract:
Amphiregulin (AREG) is an EGF-like ligand that binds EGFR to activate signaling pathways governing cellular proliferation, differentiation, tissue repair, and immune responses. This review integrates AREG's structural characteristics and signaling mechanisms with its biological functions derived from cell-based and animal models. We critically evaluate AREG's mechanistic involvement in cardiovascular, respiratory, intestinal, neoplastic, and infectious diseases, highlighting its dual roles in tissue protection and pathogenesis. The broader significance lies in discussing AREG's translational potential and associated therapeutic challenges for these diseases.
Related Concept Videos
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Mitogens and the Cell Cycle
Regulation of Angiogenesis and Blood Supply
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...