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Targeted versus Universally Offered Screening in Pediatric Emergency Departments: Cost-Effectiveness
Mark H Eckman1, Monika K Goyal2, T Charles Casper3
1Division of General Internal Medicine and the Center for Clinical Effectiveness, University of Cincinnati, Cincinnati, OH, USA.
MDM Policy & Practice
|July 2, 2026
Summary
Targeted screening for sexually transmitted infections (STIs) in adolescents is highly cost-effective in emergency departments (EDs). This strategy successfully detects and treats more STIs compared to usual care or universal screening, particularly for females.
Area of Science:
- Public Health
- Health Economics
- Adolescent Medicine
Background:
- Adolescents and young adults (AYA) account for 50% of annual sexually transmitted infections (STIs).
- Emergency departments (EDs) are frequent healthcare access points for AYA.
- EDs present a strategic opportunity for STI diagnosis and treatment.
Purpose of the Study:
- To conduct a cost-effectiveness analysis of different screening strategies for Chlamydia trachomatis and Neisseria gonorrhea (CT/GC).
- To evaluate screening approaches for adolescents and young adults in pediatric ED settings.
Main Methods:
- A decision analytic cost-effectiveness model was developed.
- The model compared three strategies: usual care, targeted screening (computerized survey), and universally offered screening.
- Analysis included costs in 2024 US dollars and effectiveness (STIs detected/treated, QALYs).
Main Results:
- Targeted screening was the most effective and costliest strategy, with an ICER of $517 per case detected and treated.
- In QALY analysis, targeted screening had an ICER of $23,320/QALY.
- Usual care was dominated (more costly, less effective) by universally offered screening; targeted screening was highly cost-effective for females but not males in QALY analysis.
Conclusions:
- Targeted screening is a highly cost-effective method for identifying and treating STIs in adolescents within pediatric EDs.
- The cost-effectiveness varies between sexes when quality of life (QALYs) is considered, particularly for males.
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