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Related Experiment Video

Updated: Jul 3, 2026

Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells
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Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells

Published on: December 13, 2024

Enabling Technologies in Vascular Biology: Microphysiological Systems, Organoids, and Beyond.

Hanieh Gholizadeh1, Kambez H Benam1,2,3

  • 1Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, PA. (H.G., K.H.B.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|July 2, 2026
PubMed
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Advanced bioengineering models improve the study of vascular diseases. These sophisticated in vitro and ex vivo systems offer better insights into complex cellular interactions and therapeutic efficacy for cardiovascular conditions.

Area of Science:

  • Bioengineering and Regenerative Medicine
  • Cardiovascular Research
  • Vascular Biology and Pathology

Background:

  • Vascular and cardiovascular diseases are primary global mortality causes.
  • Understanding complex intercellular interactions and therapeutic efficacy remains challenging.
  • Existing 2D cell models have limitations in replicating the human vascular microenvironment.

Purpose of the Study:

  • To critically review cutting-edge in vitro and ex vivo technologies for vascular biology and pathology.
  • To highlight advancements in bioengineering for modeling vascular diseases.
  • To identify challenges and knowledge gaps in current research methodologies.

Main Methods:

  • Review of existing literature on advanced bioengineering techniques.
Keywords:
atherosclerosiscardiovascular diseasescellular microenvironmentmicrophysiological systemsthrombosis

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Micropatterning and Assembly of 3D Microvessels

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Last Updated: Jul 3, 2026

Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells
04:41

Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells

Published on: December 13, 2024

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

  • Focus on 3D, mechanically dynamic models and microphysiological systems.
  • Inclusion of organoids and bioprinting for reconstructing vascular microenvironments.

    • Main Results:

    • Bioengineering has yielded powerful tools to replicate vascular microenvironments in vitro and ex vivo.
    • 3D and dynamic models offer improved predictability for studying vascular pathologies and therapies.
    • Techniques like microphysiological systems, organoids, and bioprinting are advancing vascular disease modeling.

    Conclusions:

    • Bioengineered in vitro and ex vivo models represent significant progress in studying vascular diseases.
    • These advanced models enhance the study of complex cellular interactions and therapeutic outcomes.
    • Further research is needed to address existing challenges and knowledge gaps in these technologies.