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Defining Mechanistic Parameters for Covalent CD4-Based CAR-T Cells in HIV Reservoir Control

Man Sun1, Dan Zang1, Jun Chen1

  • 1Department of Oncology, The Second Hospital of Dalian Medical University, Dalian City, Liaoning Province, China.

Journal of Medical Virology
|July 2, 2026
PubMed
Abstract

No abstract available in PubMed .

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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