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Mechanistic Insight into Self-Gelation Involved in Prescription Design for Optimization of Tablet Performance.

Xiaoqian Liu1, Weitao Fang1, Ruijie Zhang1

  • 1School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, P.R. China.

Molecular Pharmaceutics
|July 2, 2026
PubMed
Summary
This summary is machine-generated.

This study designed self-gelation tablets for indomethacin (IND) to overcome poor solubility. The novel tablets demonstrate enhanced dissolution and absorption, showcasing self-gelation as an effective drug delivery strategy.

Keywords:
Indomethacinacid−base interactionpermeabilityself-gelationsolubility and dissolution

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Drug Delivery

Background:

  • Drug gelation during formulation presents manufacturing and bioavailability challenges.
  • Poor water solubility limits the therapeutic efficacy of many drugs, including indomethacin (IND).

Purpose of the Study:

  • To design and investigate self-gelation tablets of indomethacin (IND) by incorporating small-molecule ligands.
  • To explore the mechanism of self-gelation and its impact on drug properties.
  • To evaluate the potential of this approach for enhancing drug solubility and oral absorption.

Main Methods:

  • Development of indomethacin-ligand self-gelation tablets.
  • Characterization of the gelation process, including structural and viscoelastic properties.
  • Assessment of drug amorphization and dissolution behavior.
  • Evaluation of supersaturated dissolution, membrane permeability, and oral absorption potential.

Main Results:

  • Tablets exhibited spontaneous gelation upon water contact, forming a 3D viscoelastic structure with amorphization.
  • Self-gelation was sensitive to composition, temperature, and pH.
  • IND-ligand tablets showed over 200-fold increased apparent solubility and >6000-fold higher intrinsic dissolution rate compared to pure IND.
  • Sustained supersaturated dissolution was achieved via nucleation inhibition and acid-base interactions.
  • Enhanced membrane permeability and potential for improved oral absorption were observed.

Conclusions:

  • The study elucidates the self-gelation mechanism in the designed tablet formulation.
  • Self-gelation tablet design is confirmed as an effective strategy for overcoming drug solubility defects.
  • This approach holds significant promise for enhancing the oral bioavailability of poorly soluble drugs.