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Related Experiment Video

Updated: Jul 3, 2026

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

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Nailfold Videocapillaroscopy in Pediatric Rheumatology: Established Roles, Emerging Applications, and Future

Kübra Öztürk¹, Fatih Haslak¹, Mehmet Yıldız²

¹Department of Pediatric Rheumatology, İstanbul Medeniyet University Faculty of Medicine, İstanbul, Türkiye.

Balkan Medical Journal

|July 2, 2026

Summary

Nailfold videocapillaroscopy (NVC) is a key tool for diagnosing Raynaud phenomenon and scleroderma spectrum disorders in adults and children. While promising for other pediatric rheumatic diseases, further standardization and pediatric data are needed for broader clinical use.

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Area of Science:

Rheumatology
Vascular Biology
Pediatric Medicine

Background:

Nailfold videocapillaroscopy (NVC) is crucial in adult rheumatology for evaluating Raynaud phenomenon (RP) and scleroderma-spectrum disorders.
Its utility in children is established but requires age-specific reference data for accurate interpretation.
Abnormalities may be overinterpreted in healthy children without normative pediatric data.

Purpose of the Study:

To review the current applications and future potential of NVC in pediatric rheumatology.
To highlight the role of NVC in diagnosing RP and scleroderma-spectrum disorders in children.
To explore emerging uses in other pediatric rheumatic and non-rheumatologic conditions.

Main Methods:

Review of existing literature on NVC in pediatric rheumatology.
Analysis of NVC findings in various pediatric rheumatic diseases, including juvenile dermatomyositis (JDM) and juvenile systemic sclerosis (jSSc).
Discussion of limitations and future directions for NVC standardization and application.

Main Results:

NVC effectively differentiates primary from secondary RP and aids in diagnosing scleroderma-spectrum disorders.
In JDM, NVC abnormalities correlate strongly with disease activity.
NVC findings in other pediatric rheumatic diseases are often non-specific, serving as a complementary tool.
Exploratory studies suggest NVC may reflect endothelial dysfunction in non-rheumatologic conditions.

Conclusions:

NVC is a valuable tool for RP and scleroderma-spectrum disorders in pediatric rheumatology.
Its application in JDM is a promising emerging area, correlating microvascular changes with disease activity.
Further development of age-specific reference standards, harmonized protocols, and longitudinal studies is essential for broader clinical integration.