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Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

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Related Experiment Video

Updated: Jul 3, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Diagnostic Performance of Routine Abdominal MRI for Detecting Left Ventricular Hypertrophy in ADPKD.

Yin Wang1,2, Mengjun Shen1,2, Qing Xiong1

  • 1Department of Radiology, Weill Cornell Medicine, New York, NY.

Journal of Computer Assisted Tomography
|July 2, 2026
PubMed
Summary

Left ventricular wall volume (ht-LVWV) on abdominal MRI accurately detects left ventricular hypertrophy (LVH) in autosomal dominant polycystic kidney disease (ADPKD) patients. This non-invasive method aids in assessing cardiovascular risk in ADPKD.

Keywords:
autosomal dominant polycystic kidney disease (ADPKD)height-adjusted left ventricular wall volume (ht-LVWV)left ventricular hypertrophy (LVH)

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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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Published on: October 28, 2020

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Last Updated: Jul 3, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Area of Science:

  • Cardiovascular Imaging
  • Nephrology
  • Radiology

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is associated with increased cardiovascular risk, including left ventricular hypertrophy (LVH).
  • Echocardiography is the standard for LVH diagnosis, but routine abdominal MRI in ADPKD patients may offer alternative volumetric assessment.

Purpose of the Study:

  • To evaluate the diagnostic performance of left ventricular (LV) volumetric parameters from routine abdominal MRI for detecting LVH (MRI-LVH).
  • To compare MRI-derived LVH detection against echocardiography (Echo-LVH) in ADPKD patients.

Main Methods:

  • Retrospective analysis of 156 ADPKD patients, with 27 diagnosed with LVH by echocardiography.
  • Manual segmentation of LV wall and cavity on T2-weighted abdominal MRI to calculate height-adjusted LV wall volume (ht-LVWV), LV cavity volume (ht-LVCV), and total LV volume (ht-LVV).
  • Receiver operating characteristic (ROC) curve analysis was used to assess diagnostic performance, with subgroup and sensitivity analyses performed.

Main Results:

  • Ht-LVWV showed high diagnostic accuracy for Echo-LVH (AUC=0.82, sensitivity=92%, specificity=64% at 60 mL/m).
  • Adjusting for confounders improved ht-LVWV diagnostic accuracy (AUC=0.92).
  • Ht-LVV also demonstrated good performance (AUC=0.70), while ht-LVCV had inadequate performance (AUC=0.61).

Conclusions:

  • Ht-LVWV derived from routine abdominal MRI is a promising biomarker for detecting LVH in ADPKD patients.
  • The diagnostic performance of ht-LVWV is independent of key clinical variables, supporting its use in standard ADPKD imaging protocols.
  • This MRI-derived parameter aids in renal and cardiovascular risk assessment for ADPKD patients.