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Related Experiment Video

Updated: Jul 3, 2026

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
05:41

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Published on: February 23, 2017

A Multilayered Gradient Approach to Calcium Hydroxylapatite for Enhanced Full-Face Contouring and Biostimulation.

Irene Gladstein

    Plastic and Aesthetic Nursing
    |July 2, 2026
    PubMed
    Summary

    This study presents a new protocol for calcium hydroxylapatite combined with carboxymethylcellulose (CaHA-CMC) fillers. The gradient-based approach enhances facial rejuvenation by addressing volume and skin laxity through targeted layer stimulation.

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    Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

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    Area of Science:

    • Aesthetic medicine and regenerative dermatology.
    • Biomaterials science and tissue engineering.

    Background:

    • Increasing demand for noninvasive facial contouring and soft tissue regeneration.
    • Calcium hydroxylapatite combined with carboxymethylcellulose (CaHA-CMC) offers dual-action properties as a volumizing filler and biostimulatory agent.

    Purpose of the Study:

    • To introduce a standardized, gradient-based protocol for CaHA-CMC filler injections.
    • To optimize facial rejuvenation by targeting different anatomical layers with varying dilutions.

    Main Methods:

    • Development of a standardized protocol using gradient-based dilutions of CaHA-CMC.
    • Application of highly concentrated formulations on the periosteum for skeletal projection.
    • Use of hyperdiluted solutions in the subdermal plane for neocollagenesis and skin quality improvement.
    • Integration of rheological data with injection strategies.

    Main Results:

    • The protocol allows for tailored stimulation of biomechanical characteristics across different facial layers.
    • Achieved both skeletal projection with concentrated filler and improved skin texture/laxity with hyperdiluted filler.
    • Demonstrated a layered and adaptable approach to facial rejuvenation.

    Conclusions:

    • The standardized gradient-based protocol for CaHA-CMC offers a versatile method for facial rejuvenation.
    • This approach effectively addresses both volume enhancement and skin quality improvement.
    • The protocol provides a novel, adaptable strategy for practitioners in aesthetic medicine.