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Non-Invasive Compression-Induced Anterior Cruciate Ligament (ACL) Injury and In Vivo Imaging of Protease Activity in Mice
Published on: September 29, 2023
Magnetic Resonance Imaging-based Intrinsic Anatomical Parameters as Predictors of Anterior Cruciate Ligament Injury
Nairuti Mahesh Patel1, Santosh R Konde1, Sambhaji Pawal2
1Department of Radio-diagnosis, Dr. D. Y. Patil Hospital, Pune, Maharashtra, India.
Context:
Anterior cruciate ligament (ACL) injuries are common knee injuries associated with significant morbidity and risk of long-term osteoarthritis. Despite advances in the reconstruction techniques, graft failure still remains a clinical challenge. Intrinsic anatomical factors measurable on magnetic resonance imaging (MRI) may predispose individuals to both primary ACL injury and reconstruction failure.
Aims:
To evaluate MRI-derived anatomical risk factors - posterior tibial slope (PTS), tibial tubercle-trochlear groove (TT-TG) distance, and intercondylar notch morphology and width - in ACL injury and graft failure, compared with controls.
Settings And Design:
Retrospective case-control study at a tertiary academic center in Western India.
Subjects And Methods:
One hundred adults undergoing knee MRI were grouped as ACL tear (n = 40), graft failure (n = 20), and controls (n = 40). Measurements included PTS, TT-TG distance, and notch width index (NWI) with morphology.
Statistical Analysis Used:
Continuous variables were compared using the one-way analysis of variance. Categorical variables were compared using Chi-square/Fisher's exact test.
Results:
PTS was higher in ACL injury and graft failure (11.78°, 13.95°) versus controls (10.74°). TT-TG distance was increased (15.34 mm, 15.40 mm vs. 12.44 mm). NWI was lower (0.184, 0.198 vs. 0.228). V-shaped notch was more frequent but not independently significant.
Conclusions:
Increased PTS, TT-TG distance, and reduced NWI are the significant risk factors for ACL injury and graft failure.
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