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Published on: October 12, 2017

A Study on the Levels of Lipoprotein (a) as a Predictor of Severity of Coronary Artery Disease

Aruba Usman1, K Vengadakrishnan, Sudha Madhavan

  • 1Department of General Medicine, Sri Ramachndra Institue of Higher Education and Research, Chennai, Tamil Nadu, India.

Annals of African Medicine
|July 2, 2026
PubMed

Insights

Elevated Lipoprotein (a) levels correlate with coronary artery disease severity in Indian patients. Measuring Lipoprotein (a) aids in predicting atherosclerosis progression, especially in those with normal lipid levels.

Area of Science:

  • Cardiology
  • Biochemistry
  • Public Health

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality in India.
  • Lipoprotein (a) [Lp (a)] possesses atherogenic and prothrombotic properties, linking endothelial dysfunction to atherosclerosis and thrombosis.

Purpose of the Study:

  • To investigate the correlation between Lipoprotein (a) levels and the severity of coronary artery disease.
  • To assess the utility of Lp (a) as a predictor of CAD severity in an Indian population.

Main Methods:

  • Prospective study of 18 months duration involving patients undergoing coronary angiography.
  • Correlation analysis between serum Lipoprotein (a) levels and SYNTAX scores.

Main Results:

  • A statistically significant positive correlation (r=0.36) was observed between Lipoprotein (a) levels and SYNTAX scores.
  • Mean Lp (a) level was 36.73 mg/dl; 44.16% of subjects had Lp (a) >30 mg/dl.
  • Mean SYNTAX score was 20.21; 46.75% of subjects had a SYNTAX score >20.

Conclusions:

  • Lipoprotein (a) levels are significantly associated with coronary artery disease severity.
  • Measurement of Lp (a) is recommended for risk stratification in CAD patients, including those with normolipidaemia.
  • Lp (a) can serve as a valuable biomarker for predicting the extent of coronary atherosclerosis.
Abstract

Keywords:
Coronary artery diseaseMaladie coronarienneathérosclérose coronariennecoronary atherosclerosislipidaemialipidémie

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