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Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
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Adjunctive Cilostazol Therapy for Sinus Node Dysfunction After Heart Transplantation

Kento Tamano1, Sakae Takenaka1, Toshiyuki Nagai1

  • 1Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

JACC. Case Reports
|July 2, 2026
PubMed

Insights

Cilostazol, a phosphodiesterase-3 inhibitor, may help manage severe sinus node dysfunction (SND) in heart transplant patients. This case study shows it improved heart rate and function without adverse events, potentially avoiding pacemaker implantation.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Sinus node dysfunction (SND) management after heart transplantation (HTx) is not well-established.
  • Phosphodiesterase-3 inhibitors like cilostazol have not been evaluated for this indication.
Abstract

Keywords:
atrioventricular junctional rhythmcilostazolheart transplantationsinus node dysfunction

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