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Clastogenic effects of frusemide on human leukocytes in culture
Mutation Research
|January 1, 1979
Abstract:
The clastogenic effects of frusemide were investigated in vitro for 24 and 72 h. A mitodepressive activity was observed at both times. Chromosomal anomalies showed a dose response. There was a propensity for chromatid abnormalities. The chromosome mutational property of the drug is discussed in the light of earlier studies in vivo by the authors.