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Related Experiment Video

Updated: Jul 3, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
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Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

Recent Advances in Two-Photon-Activatable Metal Complexes for Photodynamic Therapy.

Jinzhe Liang1, Hui Chao1

  • 1College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, People's Republic of China.

Angewandte Chemie (International Ed. in English)
|July 2, 2026
PubMed
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Metal complexes are advancing two-photon photodynamic therapy (TP-PDT) for cancer treatment. Enhanced photosensitizers offer deeper light penetration and improved efficacy, especially in challenging hypoxic tumors.

Area of Science:

  • Materials Science
  • Chemistry
  • Biomedical Engineering

Background:

  • Photodynamic therapy (PDT) faces limitations in light penetration and photosensitizer (PS) performance.
  • Two-photon PDT (TP-PDT) utilizes near-infrared light for deeper penetration and enhanced spatial precision.
  • Metal complexes offer tunable properties for developing advanced TP-PDT agents.

Purpose of the Study:

  • To review recent advancements in two-photon-activatable metal complexes for PDT.
  • To highlight design principles governing their photophysical and biological performance.
  • To discuss challenges and opportunities for clinical translation.

Main Methods:

  • Overview of recent research on metal-based TP-PDT agents.
  • Analysis of design strategies including ligand engineering, photo-decaging, supramolecular design, and nanostructuring.
Keywords:
hypoxiaimmunotherapyphotosensitizerstransition metal complexestwo‐photon photodynamic therapy

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Last Updated: Jul 3, 2026

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An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
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  • Focus on ruthenium, iridium, and platinum complexes.

    • Main Results:

    • Coordination design precisely controls spin-orbit coupling, excited-state dynamics, and reactive oxygen species generation.
    • Advanced strategies significantly enhance two-photon absorption, charge separation, and radical generation.
    • Improved therapeutic efficacy observed, particularly in hypoxic tumors.

    Conclusions:

    • Two-photon-activatable metal complexes show significant promise for overcoming PDT limitations.
    • Coordination chemistry plays a crucial role in optimizing TP-PDT agent performance.
    • Further development is needed for successful clinical translation.