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Related Experiment Video

Updated: Jul 3, 2026

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy
03:59

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy

Published on: January 10, 2019

Localized Cutaneous Reaction to Chlorhexidine After Lumbar Trigger Point Injections: A Case Report.

Sai S Maddike1, Timothy M Dang2, Niketa Parikh3

  • 1From the Departments of Emergency Medicine.

A&A Practice
|July 2, 2026
PubMed
Summary
This summary is machine-generated.

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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

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A patient experienced a delayed skin reaction after lumbar trigger point injections (TPIs). Increased chlorhexidine use and subcutaneous exposure during skin prep likely caused this hypersensitivity reaction.

Area of Science:

  • Dermatology
  • Allergy and Immunology
  • Pain Management

Background:

  • Trigger point injections (TPIs) are common procedures for myofascial pain.
  • Adverse reactions to TPIs are rare, but can occur.
  • Chlorhexidine is a widely used antiseptic for skin preparation.

Related Experiment Videos

Last Updated: Jul 3, 2026

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy
03:59

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy

Published on: January 10, 2019