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Related Experiment Video

Updated: Jul 3, 2026

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Published on: May 7, 2020

Contraceptive Progestogens and Incident Meningioma.

Nicklas Hasselblad Lundstrøm¹, Mette Hjorslev Knudgaard¹, Michael Skaarup Pedersen²

¹Division of Pharmacovigilance and Quality Management, Danish Medicines Agency, Copenhagen, Denmark.

JAMA Network Open

|July 2, 2026

Summary

Certain hormonal contraceptives containing progestogens, including combined oral contraceptives, progestogen-only pills, and high-dose intrauterine devices, are linked to an increased risk of meningioma. Recent use showed the highest risk, highlighting the need for physician and patient awareness.

Related Experiment Videos

Last Updated: Jul 3, 2026

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Published on: May 7, 2020

Area of Science:

Neuro-oncology
Endocrinology
Public Health

Background:

Meningiomas are known adverse effects of high-dose progestogens.
Limited data exists on meningioma risk with progestogens used for contraception.

Purpose of the Study:

To investigate the association between different progestogens used in hormonal contraception and the risk of meningioma.

Main Methods:

A nationwide Danish population-based nested case-control study.
Included 3 million females aged 15-59 years over a 25-year period.
Identified 1473 meningioma cases and 14,717 matched controls.

Main Results:

Recent use of cyproterone, desogestrel, drospirenone, gestodene, levonorgestrel (oral and high-dose IUD), and injectable medroxyprogesterone was associated with increased meningioma risk.
Odds ratios ranged from 1.38 to 4.55 for various progestogens.
Recent use (within the past year) correlated with the highest risk.

Conclusions:

Specific contraceptive progestogens are associated with an elevated risk of meningioma.
Findings are crucial for informed decision-making by women and healthcare providers.
Highlights the importance of considering progestogen type and recent use in meningioma risk assessment.