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Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
Published on: September 27, 2014
Ebola Virus in Pregnancy
Naima T Joseph1, Sonja A Rasmussen, Dana Meaney-Delman
1Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts; the Department of Genetic Medicine and the Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, and the Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; the Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; and University of Iowa Health Care, Iowa City, Iowa.
Abstract:
An Ebola virus outbreak in the Democratic Republic of the Congo has been declared a Public Health Emergency of International Concern. In recent years, substantial advances in evidence-based clinical guidelines, vaccines, and therapeutics have been made, leading to improved outcomes. Our understanding regarding pregnancy outcomes has evolved; maternal mortality rates appear lower than previously believed, but vertical transmission and neonatal death rates remain high. Information gaps persist, particularly regarding infection with Bundibugyo ebolavirus, the species responsible for the current outbreak. No licensed therapeutics or vaccines are available, although candidates are promising. Including pregnant individuals in trials is critical to generating evidence on safety and efficacy of therapeutics during pregnancy. Here we provide an update regarding Ebola virus disease and implications for pregnancy.
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