Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Cross-reactivity00:42

Cross-reactivity

Overview
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Learning from swine influenza, Ebola virus disease, and Legionnaires' disease in 1976.

Lancet (London, England)·2026
Same author

Antigenic Drift and Antivaccine Shift in the 2025-2026 Influenza Season.

The New England journal of medicine·2026
Same author

Tularemia Antimicrobial Treatment and Prophylaxis: CDC Recommendations for Naturally Acquired Infections and Bioterrorism Response - United States, 2025.

MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports·2025
Same author

Mpox Among Pregnant Women and Their Infants in the U.S. Outbreak, 2022-2023.

Obstetrics and gynecology·2025
Same author

New solutions against the dengue global threat: opportunities for Wolbachia interventions.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2025
Same author

The Rise of Mpox in a Post-Smallpox World.

Emerging infectious diseases·2024

Related Experiment Video

Updated: Jul 4, 2026

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
10:11

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

Ebola Virus in Pregnancy.

Naima T Joseph1, Sonja A Rasmussen, Dana Meaney-Delman

  • 1Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts; the Department of Genetic Medicine and the Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, and the Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; the Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; and University of Iowa Health Care, Iowa City, Iowa.

Obstetrics and Gynecology
|July 2, 2026
PubMed
Summary

Ebola virus disease outbreaks pose risks to pregnant individuals, with high rates of vertical transmission and neonatal death. Further research is crucial for developing safe and effective treatments for Ebola virus disease during pregnancy.

More Related Videos

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
05:22

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface

Published on: December 30, 2025

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
09:11

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

Related Experiment Videos

Last Updated: Jul 4, 2026

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
10:11

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
05:22

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface

Published on: December 30, 2025

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
09:11

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

Area of Science:

  • Infectious Diseases
  • Public Health
  • Obstetrics & Gynecology

Background:

  • Ebola virus disease (EVD) outbreaks, including the current one in the Democratic Republic of the Congo, are significant public health emergencies.
  • Recent advancements in EVD clinical guidelines, vaccines, and therapeutics have improved general patient outcomes.
  • Understanding of EVD in pregnancy is evolving, with lower maternal mortality but persistent high rates of vertical transmission and neonatal death.

Purpose of the Study:

  • To provide an updated overview of Ebola virus disease, focusing on its implications for pregnant individuals.
  • To highlight persistent information gaps concerning infection with specific Ebola virus species, such as Bundibugyo ebolavirus.
  • To emphasize the need for including pregnant populations in clinical trials for EVD therapeutics and vaccines.

Main Methods:

  • Review of current literature and clinical guidelines on Ebola virus disease.
  • Analysis of epidemiological data related to EVD outbreaks and pregnancy outcomes.
  • Synthesis of information on the safety and efficacy of existing and candidate EVD therapeutics and vaccines in pregnant individuals.

Main Results:

  • Maternal mortality rates in pregnant individuals with EVD may be lower than previously estimated.
  • Vertical transmission of Ebola virus and neonatal mortality rates remain high.
  • No licensed therapeutics or vaccines are currently available for EVD, though promising candidates exist.

Conclusions:

  • Pregnant individuals remain a vulnerable population during Ebola virus disease outbreaks.
  • Inclusion of pregnant women in clinical trials is essential for generating evidence on treatment safety and efficacy.
  • Further research is critical to address knowledge gaps and improve outcomes for pregnant individuals affected by EVD, particularly concerning Bundibugyo ebolavirus.