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Updated: Jul 4, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Comprehensive Approach to Prostate Cancer Metastasis Mimics at Prostate-Specific Membrane Antigen PET/CT.

Niloufar Rafiei Alavi¹, Arti Gupta¹, Maryam Rahmani¹

¹Department of Radiological Sciences, University of California, Irvine, 101 City Dr S, Orange, CA 92868.

Radiographics : a Review Publication of the Radiological Society of North America, Inc

|July 2, 2026

Summary

This summary is machine-generated.

Prostate-specific membrane antigen (PSMA) PET imaging for prostate cancer (PCa) can be misinterpreted due to non-cancerous PSMA uptake. This study details common mimics and a risk assessment approach for accurate diagnosis.

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Last Updated: Jul 4, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

Area of Science:

Nuclear medicine
Radiology
Oncology

Background:

Prostate-specific membrane antigen (PSMA) PET/CT is a key tool in prostate cancer (PCa) management.
Diagnostic accuracy can be limited by PSMA expression in non-PCa tissues, mimicking metastases.

Purpose of the Study:

To identify common and challenging mimics of PCa metastases on PSMA PET/CT.
To present a structured risk-assessment strategy for interpreting PSMA PET/CT findings.

Main Methods:

Review of PSMA PET/CT scans with known benign or malignant mimics of PCa.
Integration of uptake intensity, lesion location, anatomic imaging, and clinical data.
Application of standardized scoring systems for risk stratification.

Main Results:

PSMA expression occurs in various physiologic tissues and diverse pathologies, not exclusively PCa.
These conditions can present as false-positive findings, mimicking metastatic disease.
A systematic approach combining imaging features and clinical context improves diagnostic confidence.

Conclusions:

Accurate interpretation of PSMA PET/CT requires awareness of potential mimics.
Integrating uptake characteristics, location, and clinical information is crucial for risk assessment.
Standardized scoring systems aid in differentiating true PCa from mimics.