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Updated: Jul 4, 2026

Monitoring Influenza Virus Survival Outside the Host Using Real-Time Cell Analysis
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Monitoring Influenza Virus Survival Outside the Host Using Real-Time Cell Analysis

Published on: February 20, 2021

Hantavirus stability and inactivation.

Léna Vandenabeele1, Abraham Ayanwale2, Thomas Pietschmann2,3,4,5

  • 1Division of Virology and Immunology, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Plos Neglected Tropical Diseases
|July 2, 2026
PubMed
Summary
This summary is machine-generated.

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Hantaviruses, like Tula virus, show remarkable stability in various conditions, suggesting prolonged environmental infectiousness. Standard inactivation methods effectively neutralize these zoonotic viruses, crucial for safe handling and risk assessment.

Area of Science:

  • Virology
  • Public Health
  • Molecular Biology

Background:

  • Hantaviruses cause severe diseases like HCPS and HFRS with high fatality rates.
  • Limited molecular tools and high-containment needs hinder hantavirus research.
  • Previous studies on hantavirus stability and inactivation are not comprehensive.

Purpose of the Study:

  • Investigate Tula virus (TULV) particle production and stability in cell culture.
  • Evaluate TULV stability under various physical and environmental stresses.
  • Assess the efficacy of common inactivation methods on TULV, Andes virus (ANDV), and Hantaan virus (HTNV).

Main Methods:

  • Monitored TULV production in Vero E6 cells.
  • Assessed TULV stability at different temperatures, after dehydration, and UV exposure.

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  • Tested inactivation by RNA/protein extraction buffers in cell-free and cell-associated contexts.
  • Validated inactivation methods with ANDV and HTNV.

    • Main Results:

    • TULV demonstrated remarkable stability at room temperature, colder temperatures, and after dehydration.
    • Infectious TULV particles remained stable for extended periods under these conditions.
    • Common inactivation methods efficiently inactivated TULV, ANDV, and HTNV.
    • These methods proved effective in both cell-free and cell-associated viral samples.

    Conclusions:

    • Hantaviruses may remain infectious in the environment for extended durations.
    • Standard inactivation protocols are effective for hantaviruses, ensuring safe sample handling.
    • Findings inform environmental transmission risk assessments and laboratory safety procedures.