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Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Sanger Sequencing01:57

Sanger Sequencing

DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
Kepler's First Law of Planetary Motion01:10

Kepler's First Law of Planetary Motion

In the early 17th century, German astronomer and mathematician Johannes Kepler postulated three laws for the motion of planets in the solar system. He formulated his first two laws based on the observations of his forebears, Nikolaus Copernicus and Tycho Brahe.
Polish astronomer Nikolaus Copernicus put forth a theory that stated a heliocentric model for the solar system. According to this heliocentric theory, all the planets, including Earth, orbit the Sun in circular orbits.
On the other hand,...

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Related Experiment Video

Updated: Jul 4, 2026

Understanding Cerebellar Pattern Formation
13:18

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

250 years of promise.

H Holden Thorp1

  • 1H. Holden Thorp is Editor-in-Chief of the Science journals.

Science (New York, N.Y.)
|July 2, 2026
PubMed
Summary

Early American leaders valued scientific knowledge alongside liberty. Universities founded during this era integrated scientific study, reflecting a commitment to intellectual advancement and national progress.

Area of Science:

  • History of Science
  • American History
  • Founding Era Studies

Background:

  • The founding of America emphasized personal liberty and equality.
  • Early American leaders recognized the crucial role of scientific knowledge.
  • Educational institutions were established, reflecting a commitment to intellectual growth.

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