Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Sympathetic Signaling01:31

Sympathetic Signaling

Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epigenetic and oncogenic inhibitors converge to drive a metabolic catastrophe in castration-resistant prostate cancer.

The Journal of clinical investigation·2026
Same author

The Influence of Diet on Cancer Progression and Treatment.

Annual review of nutrition·2026
Same author

Aconitase 2 the rescue: A safeguard against excess mitochondrial citrate.

Molecular cell·2026
Same author

Pancreatic cancer-associated organ dysfunction promotes muscle autophagy and contributes to peripheral tissue wasting.

bioRxiv : the preprint server for biology·2026
Same author

A Legacy of Mentorship: A Tribute to Lewis Cantley.

Cancer discovery·2026
Same author

Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.

Cell chemical biology·2026
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
Same journal

Membrane protein solubilization and structure determination using de novo-designed proteins.

Science (New York, N.Y.)·2026
See all related articles

Related Experiment Videos

Local signals, systemic decline.

Yetiş Gültekin1,2, Matthew G Vander Heiden1,2,3,4

  • 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

Science (New York, N.Y.)
|July 2, 2026
PubMed
Summary
This summary is machine-generated.

A high-fat diet disrupts tumor-nerve communication and causes cachexia, a wasting condition, in mice. This highlights how diet impacts cancer progression and metabolic health.

Related Experiment Videos

Area of Science:

  • Oncology
  • Metabolic Research
  • Neuroscience

Background:

  • Cachexia is a complex metabolic syndrome associated with cancer, characterized by involuntary weight loss and muscle wasting.
  • Tumor-associated inflammation and altered signaling pathways are implicated in cachexia development.
  • Dietary factors are known to influence cancer progression and host metabolism.

Purpose of the Study:

  • To investigate the impact of a high-fat diet on tumor-to-nerve signaling.
  • To determine if a high-fat diet exacerbates cachexia in a mouse model.

Main Methods:

  • Mice were fed either a control or high-fat diet.
  • Tumor growth and associated nerve signaling were monitored.
  • Biomarkers of cachexia and metabolic changes were assessed.

Main Results:

  • High-fat diet significantly altered tumor-to-nerve signaling pathways.
  • Mice on a high-fat diet exhibited increased severity of cachexia, including greater muscle loss.
  • Metabolic disturbances were more pronounced in mice consuming the high-fat diet.

Conclusions:

  • A high-fat diet adversely affects tumor-nerve interactions.
  • Dietary fat intake can promote cachexia in cancer-bearing mice, suggesting a link between diet and cancer-induced wasting.