Characterization of induced pluripotent stem cell lines from patients of African American ancestry

Induced pluripotent stem cells (iPSCs) are a valuable platform for studying human biology and developing patient-specific cellular models. However, individuals of African American ancestry remain underrepresented in existing iPSC repositories, limiting the diversity of available research resources. To address this gap, we generated and characterized two iPSC lines derived from healthy donors of African American ancestry. Both lines exhibited normal morphology, expression of pluripotency markers, trilineage differentiation potential, stable karyotypes, and absence of mycoplasma contamination. Short tandem repeat analysis confirmed donor identity. These well-characterized iPSC lines provide a valuable resource for future studies investigating ancestry-specific genetic and cellular mechanisms relevant to human disease.