Related Experiment Video
Updated: Jul 4, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Targeting the ischemic cascade: Review on approved and investigational stroke therapies
Ruoyu Wang1, Zixuan Qiu1, Jian Chen1
1Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, PR China.
Abstract:
Ischemic stroke persists as a preeminent global health burden, ranking among the foremost causes of both mortality and long-term disability worldwide. This significant disease burden underscores its critical status within international public health priorities. To comprehensively address this challenge, this review adopts an epidemiological lens, systematically examining the underlying pathogenesis of ischemic stroke, evaluating contemporary clinical intervention strategies spanning prevention to acute care and rehabilitation, and critically appraising recent advances in therapeutic pharmacology. Furthermore, the review explores promising future therapeutic directions, including the ongoing quest for novel pharmacological agents and the translational potential of regenerative medicine. Collectively, this review aims to provide insights to inform evidence-based clinical decision-making while simultaneously stimulating innovative research pathways in novel pharmacotherapy development and its effective translation into clinical practice.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Ischemic Stroke l: Introduction
Stroke: Introduction and Types
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Hemorrhagic Stroke ll: Pathophysiology
