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Updated: Jul 4, 2026
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Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes
Published on: January 10, 2011
Uncovering subtype-selective activation of the KCa3.1 channel by SKA-111
1Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Structure (London, England : 1993)
|July 2, 2026
Abstract:
In this issue of Structure, Ramanishka et al.1 present cryo-electron microscopy structures of KCa3.1 and KCa2.2 channels bound to two benzothiazole-type activators, SKA-31 and SKA-111. Combined with binding energy calculations, these structures define the ligand-binding interface and explain SKA-111's subtype-selectivity for KCa3.1.
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