Related Experiment Video
Updated: Jul 4, 2026

14:42
Biology of Microbial Communities - Interview
Published on: May 28, 2007
Summary
Researchers explored the structural mechanisms behind proton inhibition in the TASK-1 potassium channel. This study reveals key insights into how protons affect channel function, impacting our understanding of ion channel regulation.
Area of Science:
- Biophysics
- Molecular Biology
- Structural Biology
Background:
- Two-pore domain potassium channels, like TASK-1, play crucial roles in regulating cell membrane potential.
- Proton sensitivity of ion channels is vital for physiological processes, but the structural basis is often unclear.
- TASK-1 channels are implicated in various physiological functions, including neuronal excitability and blood pressure regulation.
Related Concept Videos
Bystander Effect
The discussion of bullying highlights the problem of witnesses not intervening to help a victim. This is a common occurrence, as the following well-publicized event demonstrates. In 1964, in Queens, New York, a 19-year-old woman named Kitty Genovese was attacked by a person with a knife near the back entrance to her apartment building and again in the hallway inside her apartment building. When the attack occurred, she screamed for help numerous times and eventually died from her stab wounds.
Life Histories
Constrained by limited energy and resources, organisms must compromise between offspring quantity and parental investment. This trade-off is represented by two primary reproductive strategies; K-strategists produce few offspring but provide substantial parental support, whereas r-strategists produce much progeny that receives little care. These strategies are related to an organism’s survival likelihood across its lifespan, which is represented by a survivorship curve. Three general types of...
The Blood-brain Barrier
Overview
Routes of Persuasion
Persuasion is the process of changing our attitude toward something based on some kind of communication. Much of the persuasion we experience comes from outside forces. How do people convince others to change their attitudes, beliefs, and behaviors? What communications do you receive that attempt to persuade you to change your attitudes, beliefs, and behaviors?
Altruism
Altruistic behaviors are “unselfish” behaviors—those that help another individual at the expense of the individual carrying out the behavior. Despite the negative consequences for the altruistic animal, these behaviors are thought to have evolved for several reasons.
Phagocytosis
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). It is perhaps unsurprising, that many...

