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Related Concept Videos

Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo
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Long-term lessons from MATCH01 macrophage therapy in cirrhosis.

Bi-Sen Ding1, Biao Yang1, Zhongwei Cao1

  • 1State Key Laboratory of Respiratory Health and Multimorbidity, Division of Abdominal Tumor Multimodality Treatment, Center of Infectious Diseases, West China Second Hospital, West China School of Basic Medical Sciences & Forensic Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

Cell Stem Cell
|July 2, 2026
PubMed
Summary

Autologous macrophage therapy shows promise for advanced liver cirrhosis. This regenerative approach improved transplantation-free survival in a clinical trial, offering hope for liver disease patients.

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Mapping Hepatic Stellate Cell Morphology in Mouse Models of Liver Fibrosis
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Area of Science:

  • Regenerative Medicine
  • Hepatology
  • Immunology

Background:

  • Liver cirrhosis is a significant cause of liver failure worldwide.
  • Current treatments for advanced liver disease have limitations.
  • Cell-based therapies offer potential for liver regeneration.

Purpose of the Study:

  • To evaluate the long-term efficacy of autologous macrophage therapy in patients with liver cirrhosis.
  • To assess the impact of this therapy on transplantation-free survival.

Main Methods:

  • Phase 1/2 clinical trial follow-up.
  • Administration of autologous (patient-derived) macrophages.
  • Monitoring of clinical outcomes, including survival and need for liver transplantation.

Main Results:

  • Autologous macrophage therapy significantly improved transplantation-free survival.
  • The therapy demonstrated a positive impact on patients with advanced liver disease.

Conclusions:

  • Autologous macrophage therapy is a viable regenerative approach for liver cirrhosis.
  • These findings support the translational potential of macrophage-based therapies for advanced liver disease.