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From reconstruction to intervention: Engineered organoids as living therapeutic depots
Lu Wang1, Yan Pang2, Jinyao Liu1
1State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
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Wang et al. engineer mammary organoids as anticancer drug-secreting depots that inhibit post-surgical tumor recurrence and regenerate functional mammary gland tissue.1 This work extends the therapeutic utility of organoids beyond tissue reconstruction into living therapeutic depots, establishing a strategy to exploit intrinsic physiological processes of the organoids for therapeutic intervention.
