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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Updated: Jul 4, 2026

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition
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Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition

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Human stem cell-based embryo model governance: Insights from Japan.

Misao Fujita1, Kyoko Akatsuka2, Fujika Ariarakawa3

  • 1Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto-city, Kyoto 606-8507, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), KUIAS, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto-city, Kyoto 606-8501, Japan.

Cell Stem Cell
|July 2, 2026
PubMed
Summary
This summary is machine-generated.

Japan revised guidelines on April 1, 2026, to include human stem cell-based embryo model (SCBEM) research. This study analyzes the new regulations, comparing them to international standards and identifying regulatory challenges.

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Last Updated: Jul 4, 2026

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Published on: February 3, 2018

Area of Science:

  • Developmental Biology
  • Biomedical Ethics
  • Regulatory Science

Background:

  • Human stem cell-based embryo models (SCBEMs) are advancing rapidly.
  • Existing national regulatory frameworks for SCBEM research are limited.
  • International guidelines, such as those from ISSCR, provide a basis for regulation.

Purpose of the Study:

  • To examine Japan's revised guidelines for human SCBEM research implemented on April 1, 2026.
  • To compare these revisions with existing ISSCR guidelines.
  • To identify practical challenges in the international regulatory transition period for SCBEM research.

Main Methods:

  • Comparative analysis of regulatory documents.
  • Review of international scientific guidelines (ISSCR).
  • Assessment of potential implementation challenges.

Main Results:

  • Japan's revised guidelines now explicitly include human SCBEM research.
  • Key differences exist between Japanese regulations and ISSCR guidelines.
  • The transition period presents practical and ethical regulatory challenges.

Conclusions:

  • Japan's updated regulations signify a step towards harmonizing SCBEM research oversight.
  • Addressing international regulatory differences is crucial for global scientific advancement.
  • Proactive identification of challenges will facilitate smoother implementation of SCBEM research guidelines.