Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 4, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Ultra-flexible wireless endovascular stimulator for cortical simulation.

Yi-De Tai1, Joel Villalobos1, Weijie Qi1

  • 1Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia.

Journal of Neural Engineering
|July 2, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A neural mass modelling framework for evaluating EEG source localisation of seizure activity.

Journal of neural engineering·2026
Same author

Investigation of stress hormones across multiday seizure cycles.

Brain communications·2026
Same author

Toward a fully wireless endovascular neural interface: Evaluating power transfer efficacy.

PloS one·2026
Same author

"Getting to diagnosis was an absolute nightmare": survey insights about the lived experience of spinal CSF leak in Australia and Aotearoa New Zealand.

Journal of neurology·2026
Same author

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Perturbation-induced responses improved seizure forecasting in epileptic rats.

Epilepsia·2026

This study demonstrates a fully wireless, leadless endovascular stimulator for cortical stimulation. The device, delivered via catheter, successfully evoked neural responses in vivo, offering a safer alternative to traditional implants.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Minimally Invasive Devices

Background:

  • Conventional intracranial implants face challenges like foreign body responses and lead-related failures.
  • Endovascular neural stimulation (ENS) presents a less invasive alternative but current devices use transvascular leads.
  • Existing ENS systems are limited by lead-induced complications, higher impedance, and signal noise.

Purpose of the Study:

  • To demonstrate the feasibility of fully wireless cortical stimulation using a novel, leadless endovascular stimulator.
  • To develop an ultra-flexible, catheter-deliverable device for endovascular neural stimulation.
  • To overcome limitations associated with transvascular leads in current ENS devices.

Main Methods:

  • Designed a leadless ENS implant with a receiver coil, passive circuitry, and electrodes on a flexible substrate.
Keywords:
endovascular neural interfaceflexible electronicsimplantable devicesneural stimulationwireless implants

More Related Videos

Simulator Training for Endovascular Neurosurgery
08:08

Simulator Training for Endovascular Neurosurgery

Published on: May 6, 2020

Related Experiment Videos

Last Updated: Jul 4, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Simulator Training for Endovascular Neurosurgery
08:08

Simulator Training for Endovascular Neurosurgery

Published on: May 6, 2020

  • Validated wireless power transfer and stimulation output in vitro using sheep tissue.
  • Performed acute in vivo sheep experiments, placing the device subdurally and endovascularly for cortical stimulation.

    • Main Results:

    • The ENS implant generated 3-11 V monophasic pulses across varying load impedances.
    • In vivo experiments showed controlled stimulation amplitude changes with external transmitter current.
    • Evoked neural responses (N1/N2 potentials) were observed in sheep for both subdural and endovascular placements.

    Conclusions:

    • This study presents the first in vivo demonstration of a fully wireless, catheter-deliverable endovascular cortical stimulator.
    • The developed device successfully generated electrically evoked neural responses.
    • This technology offers a scalable approach for multi-site, leadless endovascular neuromodulation with reduced risks of failure and infection.