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Modified-Release Drug Delivery Systems: Rate-Programmed II

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

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Updated: Jul 4, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

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Published on: September 20, 2011

Partition-controlled drug release from polymeric nanocapsules: A physically consistent framework with

Maria Antonia S de Albuquerque¹, Douglas F de Albuquerque²

¹ICS, Universidade Federal de Mato Grosso, Avenida Alexandre Ferronato, 1200, Setor Industrial, Sinop, 78550-728, Mato Grosso, Brazil; Faculdade de Ciências da Saúde (FACISO), Av. dos Jacarandás, 885, Sinop, 78550-512, Mato Grosso, Brazil.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V

|July 2, 2026

Summary

This summary is machine-generated.

Mathematical models for drug release from polymeric nanocapsules are improved by a new partition-controlled framework. This model accurately predicts slower release for more soluble drugs, resolving inconsistencies in previous theories.

Keywords:

Controlled release Correction factor Dimensional analysis Drug release kinetics Empirical calibration Fickian diffusion Oily-core solubility Partition equilibrium Polymeric nanocapsules Solubility paradox

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Last Updated: Jul 4, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Area of Science:

Materials Science
Chemical Engineering
Pharmaceutics

Background:

Traditional models for drug release from polymeric nanocapsules use Noyes-Whitney kinetics.
These models incorrectly predict faster release for more soluble drugs, contradicting experimental data.

Purpose of the Study:

To develop a new kinetic framework for drug release from polymeric nanocapsules.
To address the paradox of inverse solubility dependence observed experimentally.

Main Methods:

Derivation of a partition-controlled kinetic framework.
Mathematical modeling and analysis of drug release kinetics.
Re-analysis of existing nanocapsule models and experimental data.

Main Results:

The new model shows release rate inversely scales with oily-core solubility.
Corrected previous models for dimensional inconsistency and tabulation errors.
Achieved high R-squared values (0.925–0.969) for multiple drug release datasets.

Conclusions:

The partition-controlled framework provides a physically plausible and dimensionally consistent explanation for drug release.
This model accurately describes drug release behavior, particularly the inverse relationship with solubility.
The findings offer a more reliable approach for predicting drug release from nanocapsules.