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Related Concept Videos

Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
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Related Experiment Video

Updated: Jul 4, 2026

Robotic Ablation of Atrial Fibrillation
11:21

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

Pulsed Field Ablation With a Variable Loop Circular Catheter in Atrial Fibrillation: Acute Outcomes From the VARIPURE

Alexandre Almorad1, Frederic A Sebag2, Mads Brix Kronborg3

  • 1Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussels - Vrije Universiteit Brussels, European Reference Networks Guard-Heart, Brussels, Belgium; Department of Cardiology, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.

Heart Rhythm
|July 2, 2026
PubMed
Summary

The variable loop circular catheter (VLCC) pulsed field ablation (PFA) system demonstrates excellent safety and effectiveness for pulmonary vein isolation in real-world atrial fibrillation patients. This study confirms high acute procedural success and efficiency with the VLCC technology.

Keywords:
VARIPULSEatrial fibrillationpulsed field ablationsafetyvariable loop circular catheterworkflow

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28:13

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Published on: February 26, 2013

Area of Science:

  • Electrophysiology
  • Cardiovascular Medicine
  • Medical Devices

Background:

  • Pulsed field ablation (PFA) using the variable loop circular catheter (VLCC) has shown promise in atrial fibrillation (AF) trials.
  • Real-world data is crucial to validate findings from initial registrational studies.

Purpose of the Study:

  • To assess the acute safety and effectiveness of first-time pulmonary vein isolation (PVI) with the VLCC system in standard clinical practice.
  • To evaluate the VLCC system within the VARIPURE substudy of the SECURE postmarket follow-up study.

Main Methods:

  • Prospective, multicenter, observational study design.
  • Data collection from Electronic Data Capture and CARTONET analytics software.
  • Primary safety endpoint: incidence of primary adverse events (PAEs); Primary effectiveness endpoint: acute procedural success via electrical isolation of pulmonary veins.

Main Results:

  • The study included 1022 AF patients across 22 European centers.
  • A low PAE rate of 0.8% was observed, with no reported stroke, transient ischemic attack, ST-elevation, coronary spasm, or acute kidney injury.
  • High acute PVI success rate of 99.8% was achieved, with procedural, left atrial dwell, and fluoroscopy times of 60.1, 38.0, and 5.2 minutes, respectively.

Conclusions:

  • PFA with the VLCC system demonstrates favorable safety and high acute efficacy in a large real-world cohort.
  • The technology shows procedural efficiency and adherence to recommended workflows, supporting its use in clinical practice.
  • These findings provide a strong basis for future investigations of VLCC PFA technology.