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Premature ventricular contractions as a target for arrhythmogenic right ventricular cardiomyopathy trials
Alessio Gasperetti1, Norman Stockbridge2, Jason D Roberts3
1Division of Cardiology, Johns Hopkins University, Baltimore, Maryland.
None:
Numerous novel therapeutic options for the treatment of arrhythmogenic right ventricular cardiomyopathy (ARVC) are being investigated. In light of the stochastic nature of sustained ventricular arrhythmia occurrence and the slow progression of structural features in patients with ARVC, the definition of primary outcomes in randomized controlled trials in this population is challenging. The use of a reduction in the premature ventricular complex burden derived from ambulatory electrocardiogram monitors has been proposed as a potential primary outcome for trials enrolling patients with ARVC. This expert review summarizes the evidence supporting premature ventricular complex burden as a key clinical metric for patients with ARVC and discusses feasibility and caveats of implementing such a metric in randomized clinical trials.
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