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Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Atherosclerosis III: Management

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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
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Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

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Related Experiment Video

Updated: Jul 4, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Revised Lipid-Lowering Therapy Guidelines in a Nationally Representative Sample.

Sridhar Mangalesh1, Zafer Akman2, Armin Nouri3

  • 1Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

American Heart Journal
|July 2, 2026
PubMed
Summary

The 2026 ACC/AHA dyslipidemia guideline will identify 15.9 million more Americans for lipid-lowering therapy. This updated guideline significantly shifts treatment recommendations for untreated adults.

Keywords:
DyslipidemiaLipid Lowering TherapyPREVENT Risk ScorePrimary Prevention

Related Experiment Videos

Last Updated: Jul 4, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Cardiology
  • Public Health
  • Clinical Guidelines

Background:

  • The 2026 ACC/AHA dyslipidemia guideline incorporates PREVENT-based risk assessment and new treatment pathways.
  • The impact of these guideline changes on lipid-lowering therapy recommendations is not yet understood.

Purpose of the Study:

  • To compare patient classification for treatment recommendations under the 2018 and 2026 dyslipidemia guidelines.
  • To assess the shift in treatment indications for U.S. adults based on the new guideline.

Main Methods:

  • A cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (2013-2023).
  • Adults aged 40-75 years were classified according to both 2018 and 2026 guidelines, with separate analysis for those on lipid-lowering therapy.
  • Treatment recommendation categories were defined for untreated adults to enable cross-classification.

Main Results:

  • The 2026 guideline recommended/indicated treatment for 37.7% of untreated adults (31.2 million), compared to 25.6% (21.2 million) under the 2018 guideline.
  • Significant reallocation occurred: 45.5% of those in the 2018 'reasonable' category moved to 'recommended/indicated' in 2026.
  • PREVENT-based pathways accounted for 33.4% of individuals recommended for treatment under the 2026 guideline.

Conclusions:

  • The 2026 dyslipidemia guideline identifies an additional 15.9 million untreated Americans aged 40-75 years for treatment consideration.
  • The updated guideline substantially increases the number of adults considered for lipid-lowering therapy.