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Appropriateness of paediatric vitamin prescribing in Vietnamese outpatient settings: associated factors
Em Canh Pham1, Tuong Vi Thi Le2, Hong Tuoi Thi Do3
1Faculty of Pharmacy, Hong Bang International University, Ho Chi Minh City, Viet Nam canhem112009@gmail.com.
Insights
Vitamin prescribing in Vietnamese pediatric outpatients showed high adherence to recommended dosages and age criteria. However, gastrointestinal disorders were linked to inappropriate dosing, especially with multivitamin products.
Area of Science:
- Pediatric pharmacology
- Nutritional science
- Public health
Background:
- Vitamin supplementation is common in children.
- Understanding prescribing patterns is crucial for optimizing pediatric care.
Purpose of the Study:
- To describe and evaluate vitamin prescribing practices in Vietnamese pediatric outpatients.
- To assess adherence to international guidelines for dosage and age appropriateness.
Main Methods:
- A cross-sectional study of 400 pediatric outpatients in a tertiary referral hospital in Vietnam.
- Analysis of prescribing patterns by vitamin type, age, BMI, and diagnosis (ICD-10).
- Assessment of dosage and age appropriateness against established international guidelines.
Main Results:
- Multivitamin complexes and vitamin B1 were the most prescribed vitamins, mainly for children aged 1-10 with respiratory disorders.
- High adherence was observed: 91.5% met recommended dosages and 98.8% were age-appropriate.
- Gastrointestinal disorders were associated with a higher likelihood of inappropriate dosing (aOR 4.92).
Conclusions:
- Pediatric vitamin prescribing in Vietnam demonstrated good adherence to dosage and age guidelines.
- Dosage deviations occurred, particularly with multivitamins and combination products, and were linked to gastrointestinal disorders.
- Recommendations include integrating weight-adjusted dosing and electronic alerts to improve accuracy in resource-limited settings.
Objective:
Vitamin supplementation is widely practised in paediatric populations. This study aims to describe and evaluate vitamin prescribing practices in paediatric outpatients.
Design:
A cross-sectional study.
Setting:
A tertiary referral paediatric hospital in Vietnam.
Patients:
400 paediatric outpatients prescribed vitamin supplements.
Main Outcome Measures:
Prescribing patterns were analysed by vitamin type, age group, body mass index (BMI) category and International Classification of Diseases, 10th Revision (ICD-10)-coded diagnosis. Dosage and age appropriateness were assessed against international guidelines (American Academy of Pediatrics/National Institutes of Health Office of Dietary Supplements/U.S. National Academy of Medicine).
Results:
Multivitamin complexes (41.3%) and vitamin B1 (27.0%) accounted for the majority of prescriptions, predominantly in children aged 1-10 years and in association with respiratory disorders (60.3%). Although 74.2% of patients had normal BMI, this group received 63.3% of combined vitamin and dietary supplement prescriptions. Overall adherence was high, with 91.5% of prescriptions meeting recommended dosages and 98.8% being age-appropriate. In multivariable analysis, gastrointestinal disorders were associated with a higher likelihood of inappropriate dosing (adjusted OR 4.92, p=0.005), while no demographic factors remained significantly associated with age-inappropriate prescribing after adjustment.
Conclusion:
Paediatric vitamin prescribing in Vietnamese outpatient settings showed high adherence to recommended dosage and age criteria. A proportion of prescriptions exhibited dosage deviations, particularly among multivitamin and combination products. Gastrointestinal disorders were associated with an increased likelihood of inappropriate dosing. To improve dosing accuracy in resource-limited settings, the integration of weight-adjusted dosing algorithms and electronic prescribing alerts may be considered. Further studies are needed to clarify contributing factors and optimise prescribing practices.
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