Related Experiment Video
Updated: Jul 4, 2026

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
Published on: May 31, 2016
Hardware Sophistications in Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease; Is the Juice Worth
Marwan Hariz1,2, Patric Blomstedt1,2
1Department of Clinical Science, Neuroscience, Umeå University, Umeå, Sweden.
Background:
New sophisticated deep brain stimulation (DBS) systems enabling steering of current and aiming at improving further motor outcome and decreasing side effects have virtually replaced old omnidirectional systems, despite being more labor-intensive and expensive.
Objectives:
The objective was to evaluate whether modern directional DBS resulted in better motor improvement compared to "old" omnidirectional DBS.
Methods:
Publications on subthalamic nucleus (STN)-DBS from the "old" period were compared to modern publications, focusing on severity of motor symptoms at baseline and motor outcome at various intervals after surgery.
Results:
Although patients from old DBS era had a more advanced disease at baseline than those treated with modern DBS hardware, they benefitted more from STN-DBS and showed a higher percentage decrease in dopaminergic medication.
Conclusions:
The new directional DBS does not result in better motor outcome compared to the older omnidirectional DBS. However, it may, in some cases, contribute to decreasing some side effects of stimulation such as dysarthria.
Related Concept Videos
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease ll: Pathophysiology
Parkinson Disease l: Introduction
Parkinson's Disease: Overview
Neural Regulation

