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Characterizing progressive cortical thinning in multiple system atrophy: a longitudinal MRI study.

Riccardo Iandolo1, Marco Aiello2, Francesco Tommasino3

  • 1IRCCS SYNLAB SDN, Naples, Italy. riccardo.iandolo@synlab.it.

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Summary
This summary is machine-generated.

Multiple System Atrophy (MSA) involves progressive cortical thinning in motor and frontal regions, alongside significant subcortical and infratentorial volume loss. This MRI study reveals widespread neurodegeneration beyond classically affected areas.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Neurodegeneration

Background:

  • Multiple System Atrophy (MSA) is typically characterized by infratentorial and striatal atrophy.
  • Longitudinal cortical changes in MSA are not well understood.

Purpose of the Study:

  • To longitudinally characterize cortical thinning and subcortical atrophy in MSA using MRI.
  • To investigate the extent and pattern of neurodegeneration in MSA.

Main Methods:

  • 36 clinically diagnosed MSA patients underwent T1-weighted MRI at baseline and follow-up (median 0.96 years).
  • State-of-the-art neuroimaging tools were used for image processing.
  • Linear mixed-effects models assessed longitudinal changes in cortical thickness and regional volumes.

Main Results:

  • Progressive cortical thinning was observed in motor, frontal, cingulate, and insular regions, affecting key functional networks.
  • Significant volume loss occurred in subcortical and infratentorial regions, including the pons, putamen, and cerebellum, exceeding cortical thinning.
  • No association was found between thinning patterns and disease severity or duration.

Conclusions:

  • MSA exhibits widespread, progressive cortical thinning and substantial subcortical/infratentorial atrophy.
  • These findings support the view of MSA as a multisystem disorder with distributed neurodegeneration.
  • Longitudinal MRI provides a comprehensive characterization of MSA progression.