Early detection of a severe autism spectrum disorder group in young children using eye-tracking measures

Yoshimasa Mamiya1, Kenji J Tsuchiya2,3, Taiichi Katayama3

  • 1Department of Psychiatry, Graduate School of Medicine, The University of Osaka, D3 2-2, Yamadaoka, Suita, 565-0871, Osaka, Japan. y.mamiya@psy.med.osaka-u.ac.jp.

Scientific Reports
|July 2, 2026
PubMed

Insights

Early identification of severe autism spectrum disorder (ASD) in young children is crucial. Eye-tracking technology using Gazefinder shows promise in identifying severe ASD cases before specialist evaluation.

Area of Science:

  • Neurodevelopmental Disorders
  • Pediatric Psychiatry
  • Ophthalmology and Vision Science

Background:

  • Diagnostic delays for autism spectrum disorder (ASD) are common in young children, particularly those with severe symptoms.
  • Early identification of severe ASD is critical for timely intervention and support.
  • Objective and feasible screening tools are needed to aid early diagnosis before specialist assessment.

Purpose of the Study:

  • To evaluate the efficacy of the Gazefinder eye-tracking system in identifying a severe ASD subgroup in a clinical setting.
  • To determine if gaze-fixation patterns can differentiate severe ASD from other conditions in young children.
  • To assess the potential of eye-tracking as an adjunctive tool for early ASD screening.

Main Methods:

  • Analysis of gaze-fixation patterns using the Gazefinder system in 442 children aged 2-6 years referred to a child psychiatry clinic.
  • Classification of participants into Severe ASD (n=42) and Other (n=400) groups based on Childhood Autism Rating Scale (CARS) scores.
  • Receiver operating characteristic (ROC) analyses to evaluate the discriminative performance of gaze-fixation indices.

Main Results:

  • Children with severe ASD showed reduced fixation on the mouth region of facial stimuli and less fixation on people compared to geometry.
  • A composite Gazefinder index achieved 85.7% sensitivity and 55.3% specificity in discriminating severe ASD.
  • Eye-tracking measures provided objective data on visual attention patterns in young children with ASD.

Conclusions:

  • Gazefinder-derived gaze-fixation indices can assist in identifying a clinically defined severe ASD subgroup in young children.
  • Eye-tracking technology offers a non-invasive, objective method to supplement existing screening and diagnostic processes for severe ASD.
  • These findings support the use of Gazefinder as an adjunctive tool for referral-related decision-making in pediatric ASD assessment.

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