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Competitive Genomic Screens of Barcoded Yeast Libraries
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Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

A one-week automated genome-wide optical pooled screen using OttoSeq

Bryce Kirby1, Matteo Di Bernardo2,3, Iain M Cheeseman2,4

  • 1Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA.

Genome Biology
|July 3, 2026
PubMed

Keywords:
AI-Driven scientific discoveryAutomated in situ sequencingCRISPR screeningCell paintingHigh throughput biologyHigh throughput computingLLM automated annotationOptical pooled screeningSingle-cell genomics

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Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...