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FT-Transformer DeepSurv: A Novel Approach to Predicting Post-Discharge Mortality in Older Adults.
Jae Yeon Chung1, Sung Hwan Ji1, Jun Sang Yoo1
1Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea.
Studies in Health Technology and Informatics
|July 3, 2026
Summary
A new AI model accurately predicts mortality risk for elderly emergency department patients, aiding advance directive discussions. It identifies inflammation and comorbidities as key factors, outperforming age alone.
Area of Science:
- Gerontology
- Artificial Intelligence in Medicine
- Health Informatics
Background:
- Validated tools for predicting mortality in older emergency department (ED) patients (≥65) are lacking.
- This gap hinders timely Advance Directive (AD) engagement for end-of-life care planning.
Purpose of the Study:
- To develop and validate an explainable machine learning model for predicting hospital discharge mortality in elderly ED patients.
- To identify key predictors of mortality beyond chronological age.
Main Methods:
- Utilized a large dataset of 41,612 electronic health records (EHR) from Samsung Medical Center (2018-2022).
- Developed and compared four predictive models, including a FT-Transformer DeepSurv model.
- Evaluated model performance using the C-Index and generalization gap.
Main Results:
- The FT-Transformer DeepSurv model achieved a high test C-Index of 0.8747.
- This model demonstrated the smallest generalization gap (0.015) among the compared models.
- Inflammation and comorbidity burden were identified as more significant predictors of mortality than age.
Conclusions:
- An explainable AI model can accurately predict discharge mortality in elderly ED patients.
- This tool can support safer discharge planning and facilitate proactive AD discussions for high-risk individuals.
- The model highlights the importance of biological factors (inflammation, comorbidities) over age in mortality prediction for this demographic.
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