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Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

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Non-nitro-Containing Biocidal Compounds: Balancing the Energy and Biocidal Properties by Incorporating Furazans.

Jinjie Chang^1,2,3, Yuting Tian¹, Zihui Wang¹

¹School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng, Shandong 252000, China.

Organic Letters

|July 3, 2026

Summary

This summary is machine-generated.

New energetic biocidal materials were developed using furazan-based compounds. These compounds show high iodine content and effectively kill Staphylococcus aureus, offering advanced solutions for biosecurity challenges.

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Biofilm Removal Using Carbon Dioxide Aerosols without Nitrogen Purge

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Published on: November 6, 2016

Area of Science:

Materials Science
Organic Chemistry
Biochemistry

Background:

Infectious diseases necessitate the development of advanced energetic biocidal materials.
Existing biocidal materials often have limitations in efficacy or safety.

Purpose of the Study:

To synthesize novel azo- and azoxy-bridged furazan-based compounds.
To evaluate the energetic properties and biocidal efficacy of these new compounds.

Main Methods:

One-step synthesis of furazan-based compounds from 3-amino-4-iodo-1,2,5-oxadiazole.
Characterization of synthesized compounds, including iodine content, detonation velocity, and detonation pressure.
Assessment of biocidal activity against Staphylococcus aureus.

Main Results:

Synthesized (E)-1,2-Bis(4-iodo-1,2,5-oxadiazol-3-yl)diazene and its azoxy derivative with high iodine content (60.7% and 58.5%).
Achieved high detonation velocities (5633 and 5921 m s⁻¹) and detonation pressures (21.68 and 23.63 GPa).
Demonstrated 99.9% killing of Staphylococcus aureus with significant gas production.

Conclusions:

The novel furazan-based compounds possess excellent energetic properties comparable to nitro-analogues.
These compounds show potent biocidal activity, addressing biosecurity challenges.
The study presents a rational design strategy for advanced energetic biocidal materials.