Jove
Visualize
Contact Us

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Umbelliprenin co-formulated with selenium nanoparticles downregulates MMP-2, MMP-9 and ICAM-1 expression in triple-negative breast cancer cells MDA-MB-231.

BMC complementary medicine and therapies·2026
Same author

Fenugreek (Trigonella foenum-graecum) and its Active Compounds, Diosgenin and Trigonelline, in the Prevention of Cancer and Aging: A Systematic Review of Preclinical Studies.

Current drug research reviews·2026
Same author

The transformative role of artificial intelligence in gestational diabetes mellitus: advancements in screening, management, and long-term outcome prediction.

Journal of diabetes and metabolic disorders·2026
Same author

Anti-diabetic drugs: a novel therapeutic approach against cisplatin-induced kidney injury, a mechanistic review of preclinical studies.

Journal of diabetes and metabolic disorders·2026
Same author

Therapeutic impacts of oral anti-diabetic drugs on Inflammatory Bowel Disease (IBD), a comprehensive review of clinical and preclinical studies.

Naunyn-Schmiedeberg's archives of pharmacology·2025
Same author

Exploring the Role of Alpha Lipoic Acid in the Treatment of Traumatic Brain Injury: Pathways and Perspectives.

Neurocritical care·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 4, 2026

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis
06:39

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Curcumin as a Multifaceted Epigenetic Modulator With a Disease-Oriented Perspective.

Hedieh Sadat Shamsnia1,2, Mahtab Roustaei1,2, Amirreza Peyrovinasab1,2

  • 1Department of Toxicology & Pharmacology, TeMS.C., Islamic Azad University, Tehran, Iran.

Phytotherapy Research : PTR
|July 3, 2026
PubMed
Summary

Curcumin, a compound from turmeric, modifies epigenetics by inhibiting DNA methyltransferases and histone deacetylases. This epigenetic modulation offers therapeutic potential across various diseases, including cancer and neurodegenerative conditions.

Keywords:
DNAPhytomedicineRNAcurcuminepigenetichistone

Related Experiment Videos

Last Updated: Jul 4, 2026

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis
06:39

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Area of Science:

  • Epigenetics and Molecular Biology
  • Natural Product Chemistry

Background:

  • Curcumin, derived from turmeric, possesses known therapeutic properties.
  • Epigenetic modifications, including DNA methylation and histone alterations, are crucial in disease pathogenesis.
  • Curcumin's mechanism of action involves significant epigenetic modulation.

Purpose of the Study:

  • To review curcumin's role as an epigenetic modulator.
  • To explore curcumin's therapeutic potential in various diseases through an epigenetic lens.
  • To provide a disease-oriented perspective on curcumin's epigenetic activities.

Main Methods:

  • Literature review of curcumin's effects on epigenetic mechanisms.
  • Analysis of curcumin's impact on DNA methyltransferases (DNMTs) and histone deacetylases (HDACs).
  • Examination of curcumin's modulation of non-coding RNAs, including microRNAs (miRNAs).

Main Results:

  • Curcumin inhibits DNMTs, reversing gene silencing.
  • Curcumin downregulates HDACs and promotes histone acetyltransferase (HAT) activity.
  • Curcumin modulates non-coding RNA expression, impacting inflammatory and neuronal pathways.
  • Curcumin demonstrates broad-spectrum therapeutic effects in cancer, neurodegeneration, metabolic, and inflammatory diseases.

Conclusions:

  • Curcumin acts as a potent epigenetic modulator.
  • Its ability to influence DNA methylation, histone modifications, and non-coding RNAs underlies its therapeutic efficacy.
  • Curcumin presents a promising therapeutic agent for diverse pathologies via epigenetic regulation.