Brain-Derived Neurotrophic Factor and Associated Signaling in Kidney Diseases
Cheng Xue1,2, Qingqing Wei2, Shixuan Wang2
1Department of Nephrology, Shanghai Changzheng Hospital, Shanghai, China.
Summary
Brain-derived neurotrophic factor (BDNF) plays a crucial role in kidney health. The BDNF-TrkB signaling pathway shows promise for protecting and regenerating kidneys affected by diseases like CKD and AKI.
Area of Science:
- Neuroscience
- Nephrology
- Molecular Biology
Background:
- Brain-derived neurotrophic factor (BDNF) is a neurotrophin primarily known for neuronal function.
- Emerging evidence highlights BDNF's significant, non-neuronal roles, especially in kidney pathophysiology.
- The TrkB receptor mediates BDNF's cellular effects.
Purpose of the Study:
- To review recent advancements in understanding the BDNF/TrkB signaling pathway in kidney diseases.
- To explore the therapeutic potential of targeting BDNF-TrkB for renal protection and regeneration.
Main Methods:
- Literature review of studies investigating BDNF/TrkB signaling in renal contexts.
- Analysis of molecular mechanisms underlying BDNF's effects in kidney disease models.
- Summary of clinical and preclinical findings related to BDNF-TrkB in nephrology.
Main Results:
- BDNF binding to TrkB activates key intracellular pathways (PI3K-Akt, MAPK-ERK, PLCγ).
- These pathways promote cell survival, enhance mitochondrial function, maintain cytoskeletal integrity, and mediate anti-inflammatory responses in the kidney.
- Dysregulation of BDNF-TrkB signaling is implicated in chronic kidney disease (CKD) and acute kidney injury (AKI).
Conclusions:
- The BDNF-TrkB pathway is a critical regulator in various kidney diseases.
- Targeting the BDNF-TrkB pathway offers a promising strategy for renal protection and regeneration.
- Further mechanistic and clinical research is warranted to fully exploit its therapeutic potential.
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