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Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
Introduction Cardiac Emergencies01:30

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Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
Graves Disease II: Pathophysiology01:24

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Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
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Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...

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In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
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[Thyrotoxic crisis with cardiogenic shock].

Sarah Chehri1, Susanne Glacius Tischer2, Annette Ulrich3

  • 1Anæstesiologisk Afdeling, Københavns Universitetshospital - Amager og Hvidovre Hospital.

Ugeskrift for Laeger
|July 3, 2026
PubMed
Summary
This summary is machine-generated.

Thyrotoxic crisis is a life-threatening emergency. Despite intensive care and emergency thyroidectomy, a patient experienced cardiac arrest and died, highlighting the need for prompt diagnosis and multidisciplinary management.

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Area of Science:

  • Endocrinology
  • Critical Care Medicine
  • Cardiology

Background:

  • Thyrotoxic crisis is a severe, life-threatening endocrine emergency.
  • It necessitates prompt recognition and integrated multidisciplinary care for optimal outcomes.
  • Cardiovascular complications, including cardiogenic shock and cardiac arrest, are significant risks.

Purpose of the Study:

  • To present a case report of a patient with thyrotoxic crisis who developed refractory cardiogenic shock and cardiac arrest.
  • To emphasize the challenges in managing severe thyrotoxic crisis, even with advanced interventions.
  • To underscore the critical role of early diagnosis and coordinated interdisciplinary management.

Main Methods:

  • Case report of a 59-year-old woman with thyrotoxic crisis.
  • Inclusion of intensive medical therapy and emergency thyroidectomy.
  • Preparation of extracorporeal membrane oxygenation as rescue support.

Main Results:

  • The patient developed cardiogenic shock and cardiac arrest despite intensive therapy.
  • Postoperative collapse persisted following emergency thyroidectomy.
  • The patient expired shortly after the surgical intervention.

Conclusions:

  • Severe thyrotoxic crisis can lead to fatal cardiovascular complications despite maximal medical and surgical interventions.
  • The case highlights the critical importance of early identification and prompt, coordinated interdisciplinary care in managing thyrotoxic crisis.
  • Aggressive management strategies, including surgical intervention and mechanical support, may not always prevent adverse outcomes in the most severe cases.