Is There Any Difference in the Novel Serum Inflammatory Biomarkers of Adolescents With DMDD and Bipolar Disorder?

The current study compares the novel serum inflammatory biomarkers of adolescents with disruptive mood dysregulation disorder (DMDD) and bipolar spectrum disorder (BPSD) between the ages of 12 and 18. This study included 24 adolescents with DMDD, 24 adolescents with BPSD, and 24 healthy controls. All adolescents in the study were assessed for novel serum inflammatory biomarkers, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), aggregate index of systemic inflammation (AISI), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). The Affective Reactivity Index was used to assess the degree of irritability. All novel serum inflammatory biomarkers showed significant differences between the groups, with healthy adolescents scoring statistically significantly lower. NLR and PLR were positively correlated with the degree of irritability in all groups. The findings of this study may support that inflammation may play a role in mood disorders.