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Related Experiment Video

Updated: Jul 4, 2026

Extraction of Lignin with High β-O-4 Content by Mild Ethanol Extraction and Its Effect on the Depolymerization Yield
10:18

Extraction of Lignin with High β-O-4 Content by Mild Ethanol Extraction and Its Effect on the Depolymerization Yield

Published on: January 7, 2019

Valorizing ginseng residues using dimethyl ether: Recovering functional lipids and ginsenosides.

Sabrinna Wulandari1, Ruqian Cao2, Jongho Choi2

  • 1School of Chemical Engineering, Sungkyunkwan University, 2066, Seobu-Ro, Jangan-Gu, Suwon, Gyeong Gi-Do, 16419, Republic of Korea.

Journal of Ginseng Research
|July 3, 2026
PubMed
Summary

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Dimethyl ether (DME) efficiently extracts valuable ginseng oil from red ginseng marc (RGM). This green solvent method optimizes yield and bioactive compounds, offering a cost-effective alternative for industrial applications.

Area of Science:

  • Green Chemistry
  • Natural Product Extraction
  • Biotechnology

Background:

  • Red ginseng marc (RGM) is a byproduct rich in lipids and bioactive compounds.
  • Conventional extraction methods for RGM are costly due to harsh conditions and solvent removal.

Purpose of the Study:

  • To evaluate dimethyl ether (DME) as a green solvent for extracting ginseng oil from RGM.
  • To optimize extraction parameters using response surface methodology (RSM).

Main Methods:

  • DME was used as a solvent for ginseng oil extraction from RGM.
  • Response surface methodology (RSM) analyzed the effects of temperature, pressure, and time.

Main Results:

  • Optimal conditions (333 K, 7 MPa, 80 min) yielded 3.37% extraction with high ginsenoside and phenolic content.
Keywords:
DMEFatty acidsGinsengGinsenosidesRed ginseng marc

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  • DME-extracted oil showed superior antioxidant activity and fatty acid methyl ester (FAME) content compared to ethanol and hexane extracts.
  • DME allowed direct extraction from wet RGM, improving yield and ginsenoside content.
  • Conclusions:

    • DME is a versatile and energy-efficient solvent for extracting bioactive ginseng oil from RGM.
    • The process is suitable for both dry and wet RGM, with practical applications in food and cosmetics.