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Related Concept Videos

Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...

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Related Experiment Video

Updated: Jul 4, 2026

Fabricating Multi-Component Lipid Nanotube Networks Using the Gliding Kinesin Motility Assay
05:16

Fabricating Multi-Component Lipid Nanotube Networks Using the Gliding Kinesin Motility Assay

Published on: July 26, 2021

Lipid Network Crosslinked Hydrogels: Controlling Material Dynamics Across Multiple Length Scales Through Lipid

Neil J Baugh, Michelle S Huang, Narelli de Paiva Narciso

    Biorxiv : the Preprint Server for Biology
    |July 3, 2026
    PubMed
    Summary

    Synthetic hydrogels now mimic natural materials by controlling network dynamics at multiple scales. Lipid Network Crosslinked (LINC) hydrogels use mobile lipid crosslinks for independent control over macroscale and nanoscale properties.

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    Fabricating Multi-Component Lipid Nanotube Networks Using the Gliding Kinesin Motility Assay
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    Published on: July 26, 2021

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    Preparation of DNA-crosslinked Polyacrylamide Hydrogels
    09:06

    Preparation of DNA-crosslinked Polyacrylamide Hydrogels

    Published on: August 27, 2014

    Area of Science:

    • Biomaterials Science
    • Polymer Chemistry
    • Cellular Engineering

    Background:

    • Replicating natural material's multi-scale network dynamics in synthetic hydrogels is challenging.
    • Current hydrogel strategies link macroscale and nanoscale dynamics via crosslink kinetics.

    Purpose of the Study:

    • Introduce Lipid Network Crosslinked (LINC) hydrogels inspired by biological materials.
    • Enable independent control over hydrogel macroscale and nanoscale dynamics.
    • Investigate LINC hydrogels for applications requiring multi-scale dynamic control.

    Main Methods:

    • Utilized self-assembled liposomes with mobile lipids as covalent crosslinking points.
    • Designed liposomes by tuning surface functionalization and tail saturation.
    • Incorporated cell-adhesive ligands with varying mobility within the hydrogel network.

    Main Results:

    • LINC hydrogels exhibited over 20-fold increased stress relaxation rates compared to polymer-only hydrogels.
    • Liposome design parameters independently controlled macroscale storage moduli and stress relaxation.
    • Human neural progenitor cells showed altered phenotypes based on nanoscale ligand dynamics within LINC hydrogels.

    Conclusions:

    • LINC hydrogels successfully decouple macroscale and nanoscale network dynamics.
    • Lipid mobility within liposomes offers a novel strategy for biomimetic material design.
    • LINC hydrogels provide a platform for studying cell responses to tunable multi-scale material dynamics.