Related Experiment Video
Updated: Jul 4, 2026
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
Published on: July 6, 2022
Fault-tolerant 3D reconstruction from 2D spatial proteomics sections
Zhaojun Zhang1, Yuqi Tan2,3, Michael Snyder4
1Department of Statistics and Data Science, The Wharton School, University of Pennsylvania, PA, United States.
None:
Reconstructing 3D molecular volumes from sparsely sampled 2D tissue sections is limited by per-section marker dropout and tissue loss. We present 3D-Omics-Flow, a generative pipeline that jointly repairs damaged sections and interpolates between them at single-cell resolution. Across datasets spanning health and disease, 3D-Omics-Flow expands 3D spatial proteomics to practical sampling regimes, enabling atlas construction and downstream analysis from imperfect 2D section stacks.
