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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...

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Related Experiment Video

Updated: Jul 4, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

EpiATLAS - a reference for human epigenomic research.

, Quirin Manz, Misha Bilenky

    Biorxiv : the Preprint Server for Biology
    |July 3, 2026
    PubMed
    Summary
    This summary is machine-generated.

    The International Human Epigenome Consortium (IHEC) created EpiATLAS, a comprehensive resource of over 2000 human reference epigenomes. This integrated ecosystem maps the epigenomic landscape, revealing insights into cellular functions and disease associations.

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    Related Experiment Videos

    Last Updated: Jul 4, 2026

    Pattern-based Search of Epigenomic Data Using GeNemo
    06:38

    Pattern-based Search of Epigenomic Data Using GeNemo

    Published on: October 8, 2017

    A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies
    08:04

    A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

    Published on: August 13, 2020

    An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
    10:41

    An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

    Published on: April 5, 2018

    Area of Science:

    • Genomics and Epigenomics
    • Molecular Biology
    • Bioinformatics

    Background:

    • The human genome sequence is foundational to understanding health and disease.
    • Cell-specific genome interpretation relies on epigenetic processes for organization.
    • Epigenetic alterations are increasingly linked to human diseases.

    Purpose of the Study:

    • To create a unified resource of human reference epigenomes.
    • To standardize epigenomic data processing and accessibility.
    • To explore relationships between regulatory layers and cellular functions/diseases.

    Main Methods:

    • Uniform processing of over 2000 human epigenomes by the International Human Epigenome Consortium (IHEC).
    • Development of standardized molecular and bioinformatics protocols.
    • Creation of the Epigenome Reference Registry for data access and sharing.

    Main Results:

    • The EpiATLAS ecosystem provides a comprehensive map of the human epigenomic landscape.
    • Uncovered previously unappreciated relationships among regulatory layers.
    • Revealed how epigenetic inputs influence fundamental cellular functions and disease associations.

    Conclusions:

    • EpiATLAS is an unprecedented resource for biosciences.
    • The integrated ecosystem facilitates deeper understanding of epigenomic regulation.
    • Provides a foundation for future research into epigenetics and human disease.